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Patient FAQs

1. Whole genome sequencing, a test ordered by a doctor at Smith Family Clinic that looks at 20,000 genes associated with more than 1200 medical conditions, including cancer and rare diseases such as ALS and cystic fibrosis.

2. A clinical pharmacogenomic test also ordered by the Smith Family Clinic doctor. It informs patients whether specific medications will or won’t work for them to treat certain conditions, or if a medication will work differently than an average prescribing dose or frequency.
Whole genome sequencing is designed to determine the entire genetic makeup of an individual by sequencing all their DNA -- three billion letters long. That genetic code is then analyzed to identify variants, or changes in the DNA, that signify disease risk or other conditions or traits.
Any adult may participate in the Insight Genome. Potential reasons to consider the Insight Genome include, but are not limited to:

  • Individuals seeking to augment existing but sparse family health history
  • Individuals seeking additional information to guide preventive care decisions
  • Individuals interested in personalized medicine and genomics
  • Adoptees with no documented family health history
The cost of the Insight Genome is approximately $7000. That includes the whole genome sequencing test, the pharmacogenomic test, and physician visits at the Smith Family Clinic for Genomic Medicine.
The Insight Genome is self-pay.
The Insight Genome begins with clinical tests and thus must be ordered by a physician. You will see a physician at the Smith Family Clinic for Genomic Medicine. Blood and saliva samples will be taken and the doctor will order the tests. When the clinical test reports are ready, those reports will be returned to the physician at the Smith Family Clinic, who will share those results with you. A genetic counselor will also be present to help interpret your test results.
Genetic counseling is important to understand the information provided through the Insight Genome test. Most variants identified are not determinative (meaning you will get a disease) but indicate a risk. That risk can be explained through genetic counseling.

Additionally, it’s important to note that due to the nature of genetic testing, the patient is not the only individual potentially affected by findings. What is discovered may potentially impact family members, because genetic variants by their nature run in families. It may be helpful to have pre-test discussions with family members to ascertain what, if any, information they want disclosed-- and what you may be willing to disclose.
The Genetic Information Nondiscrimination Act of 2008 (GINA) protects individuals from having their genetic information used against them when obtaining employment or health insurance. Protected genetic information includes family history, participation in genetic testing or counseling, and specific genetic test results. However, this protection does not apply to other types of insurance, including life insurance and long term care policies. For more information: https://www.genome.gov/10002328
The turnaround time for the Insight Genome is approximately 90 days.
The Insight Genome includes a physician-ordered clinical test and becomes part of an individual’s medical record.
If you become a patient, all information that you and your physicians provide will become a part of your medical record, which will be protected by law and kept confidential. Click here to view our Notice of Privacy Practices.
The Smith Family Clinic for Genomic Medicine is staffed with clinical geneticists and genetic counselors. We are happy to answer their questions-- and yours.
We encourage potential patients to have conversations about genetic testing with family members in advance of doing the Insight Genome test. The information you learn from this test could potentially impact other family members, some of whom may not want to have that information.