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Insight Genome

The Smith Family Clinic for Genomic Medicine offers the Insight Genome program for adults interested in unlocking their genetic code. Your unique genetic code holds information that could help you make future health and wellness decisions in consultation with your physician.

The Insight Genome program includes:

Consult appointment at the clinic with a clinical geneticist and genetic counselor

Clinical whole genome sequencing test

Pharmacogenomic test

Discussion of test results with a clinical geneticist and genetic counselor

Clinical Whole Genome Sequencing

Every individual has about six billion “letters” in their DNA sequence. Those letters make up their genome. What makes every human unique is the four to six million letters that are different. Unless you are an identical twin, no one else shares your exact genetic makeup. Those four to six million differences are called variants.  Most DNA variants do not have an impact. Some of those variants are responsible for differences such as hair or eye color, the shape of your nose, or your adult height. Other variants are linked to disease.

Genome sequencing will look for variants in your DNA that may impact health and disease risk. Some DNA variants that are found may help explain current symptoms. Other variants may show that you have a higher risk of getting a disease in the future. For example, variants in certain genes cause a higher risk for colon cancer. In other cases, a variant may not impact your health, but may be passed on and impact the health of your children. In this case you would be a carrier of the disease.

Sometimes it is not clear whether a DNA variant is harmless or if it causes a disease.   It is possible that genome sequencing will find variants that cannot be fully understood. In Insight Genome, uncertain variants are reported that could be related to your personal and family medical history. These may be important to you as we learn more about what they mean.

The clinical whole genome sequencing test will be ordered by a physician at the Smith Family Clinic for Genomic Medicine. The doctor will provide the testing lab with information about your specific medical history and family history. The testing lab will use this information to improve their analysis of your genome.

Results from your clinical genome sequencing test will be returned to the Smith Family Clinic. A physician and genetic counselor at the clinic will share those results with you. That discussion will include DNA variants that explain current symptoms, increase your risk for future disease, or show that you are a carrier for disease.

Pharmacogenomic Testing

Pharmacogenomic testing provides information about many different genes and how they impact your body’s response to over one hundred drugs. For example, DNA variants can show that you need a higher or lower dose of a certain drug or that a different drug should be used instead. Pharmacogenomics is one piece of information that can be used by your doctor to make medication decisions. A physician at the Smith Family Clinic for Genomic Medicine will order a pharmacogenomic test in addition to the genome sequencing test described above.